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KMID : 0854720080280010045
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Korean Journal of Asthma, Allergy and Clinical Immunology
2008 Volume.28 No. 1 p.45 ~ p.52
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An Interaction Model of IL-4 and IFN-gamma Gene SNPs in Relation to Atopy
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Lee June-Hyuk
Uh Soo-Taek
Park Byung-Rae
Shin Hyoung-Doo
Jang An-Soo
Park Jong-Suk
Park Sung-Woo
Kim Do-Jin
Park Choon-Sik
Kim Yong-Hoon
Choi Jong-Hyo
Yun Jin-A
Rhim Tai-Youn
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Abstract
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Background: Asthma is a common complex genetic disease. While the T-helper cell 1 pathway is determined by cytokine interferon-gamma (IFN-gamma), the T-helper cell 2 pathway is determined by IL-4. These comprise two alternative CD4+ T-cell fates with functional consequences for the host immune system. We investigated the effect of interaction between and IL-4 SNPs on asthma or atopy.
Method: Three hundred asthmatics and 300 unrelated normal controls were enrolled. Two candidate SNPs of the IFN-gamma gene and two SNPs of the IL-4 gene were selected. Gene-gene interactions were tested using the multi-factor dimensionality reduction (MDR) method and interaction information analysis on the basis of Shannon entropy.
Result: In MDR analysis, a combination of IFN-gamma+2459A>G and IL-4-589C>T was the best model to predict atopy. In interaction information analysis, there was a strong effect of interaction between theses two SNPs on atopy. This combination showed a stronger effect than each SNP alone. In addition, IL-4-589C>T showed a strong effect on atopy with IFN-gamma+2671C>T and with IFN-gamma+2459A>G. Theses effects were prominent in normal controls.
Conclusion: From the findings of a statistical interaction model, it is suggested that IFN-gamma and IL-4 gene SNPs may contributes to the development of atopy by interacting with each other.
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KEYWORD
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Atopy, Epistasis, Polymorphism, IL-4, IFN-gamma
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